Sometimes, this error can be corrected by itself, as the error message pops up only once and the applications run in the second or third attempt. BUT this does not mean it should be left untreated, hence it needs to be fixed manually, as it may come back.
If you have the Microsoft’s Compatibility Viewer then uninstall it and try to open the Excel file. If it doesn’t work then repair the Microsoft Office (from the programs and features window) and then check.
Method 1: Disabling Run program as administrator
Select Properties by Right clicking on the shortcut of the applications showing the error message and select the Compatibility tab.
Uncheck the Run program as administrator box if its checked or enabled.
Method 2: Checking DDE Option (Excel)
Open MS Office EXCEL and open Excel Options box from the OFFICE Menu by clicking on the Office icon on the top left corner of the application and click on Advanced Locate the option called Ignore other applications that use Dynamic Data Exchange (DDE) under General Options and uncheck/disable it. Restart the office application after applying changes.
If the Ignore other applications that use Dynamic Data Exchange (DDE) option is unchecked or disabled, enable the option from the check box and restart the office application and then again uncheck the option and restart the office application.
Method 3: Change Excel Settings
There are a few settings that you can change to see if it helps. There are a lot of options that you can change but you don’t have to change all of these settings. You can change the settings one-by-one and keep checking if the problem is resolved.
Method 4: Registry Fix
Even if the method 1 didn’t work for you there is still hope for you. There is a registry fix that has worked for a lot of users. Follow the steps given below to fix the issue via the registry. Note: Messing up registry keys can cause serious issues. So, it is advised to make a backup of your registry keys in case something goes wrong. Click here for a step-by-step guide on how to backup and restore your registry.
Once done, check if the issue is resolved or not.
Method 5: Check and Disable Excel Add-ins
Sometimes the Excel add-ins might cause this issue. If you recently installed an add-in or around the time when this problem started then that is an indicator as well. Even if you don’t remember, disabling or uninstalling the add-ins from your Excel is worth a try.
This should do the job for you. If the problem is resolved then it’s clear that an add-in was causing the issue. You can now follow the above given steps and enable the add-ins one-by-one to determine which add-in was the root of the problem.
Method 6: Disable Dell Data Protection Security Authentication Service
Note: This method is for Dell users. If you aren’t using a Dell computer then skip this method. If you have a Dell machine then the issue might be related to the Dell Data Protection Security Authentication Service. This is a service installed via Dell’s Digital Delivery service. Its main purpose is to provide security solution and authentication support. The reason behind the problem relating to this service is not known but there are a ton of Dell users who solved their issue by disabling or uninstalling this Dell service. The steps to disable the Dell Data Protection Security Authentication Service are given below
Check if the issue is resolved. If the problem is gone then you know the culprit behind the issue. You can keep this service disabled without facing any major issues. You can also uninstall this service from the Programs and Features window if you really don’t want the service. On the other hand, if the problem still persists then you can simply turn on the service back again. Just follow the steps from 1-6 above but select the Automatic option in step 4.
Method 7: Disable Hardware Acceleration
The problem might also be caused by your video card. So, disabling this option solves the issue. This isn’t a solution but more of a workaround. So, keep checking for the latest updates from your video card manufacturer because there’s a high likelihood that your card manufacturer will release an update for this issue.
Once done, this should solve the issue. Keep this option enabled until you see a new update from your video card manufacturer. You should disable this option after updating the video card. If this method doesn’t solve the issue then there’s no need to keep this option enabled. Simply follow the steps given above and Uncheck the Disable Hardware Acceleration option in the step 5.
Method 8: Reset Default Programs and File Associations
Sometimes the issue can be caused the Excel isn’t the default program to run the .xlsx files. Simply making Excel the default program and resetting the file associations solves this issue for us. Follow the steps given below to reset the file associations
Method 9: Uninstalling Additional Office Viewer:
This error message may also occur, if you have installed Office Viewer next in conjunction to Microsoft Office. If this is the case, uninstall it and re-test.
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